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Year : 2018  |  Volume : 4  |  Issue : 2  |  Page : 67-69

The application of next-generation sequencing to validate D12S391 microvariation

1 Department of Forensic Biology DNA, Forensic Science Service of the Beijing Public Security Bureau, Beijing, China
2 Department of Forensic Biology, Beijing Police College, Beijing, China
3 The Jinci College of Shanxi Medical University, Taiyuan, China
4 Department of DNA Testing, Beijing Tongda Shoucheng Institute of Forensic Science, Beijing, China
5 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

Correspondence Address:
Dr. Qingxia Zhang
Forensic Science Service of the Beijing Public Security Bureau, Beijing 100192
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfsm.jfsm_62_17

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Objective: In a paternity case, the D12S391 locus was reported as a mismatch. To confirm the existence of mutations and mutations come from father or mother. Methods: STR and next-generation sequencing technology were used to validate the sequence. Results: NGS showed the loss of one adenine between the 19.3 allele of the child and allele 20 of the mother. Conclusion: The NGS can be applied in the paternity to validate the mutation.

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